Antibiotic Resistance Is a ‘Ticking Time Bomb’

Via: RSC

13 March 2013Ned Stafford

Global research efforts to develop new antibiotics need to be accelerated urgently, the UK government’s chief medical officer has warned. She adds that that new drugs are desperately needed to fight the ‘catastrophic threat’ of growing antimicrobial resistance.

In the second part of her annual report Dame Sally Davies focuses on antimicrobial resistance and infectious diseases. She says that the development of new antibiotics has stalled since the late 1980s because ‘there are fewer economic incentives’ to produce new antimicrobial agents than for other classes of drugs.

In the meantime, new infectious diseases are emerging every year and diseases thought to be under control are becoming resistant to antibiotics. Describing antimicrobial resistance as an international problem, she says global action and a partnership between the private sector, public institutions and academia is required to mount an effective response.
Time bomb

‘Antimicrobial resistance is a ticking time bomb not only for the UK but also for the world,’ she says. ‘We need to work with everyone to ensure the apocalyptic scenario of widespread antimicrobial resistance does not become a reality. This is a threat arguably as important as climate change.’
‘The low-hanging fruit in antibiotic drug discovery has almost certainly been harvested’Davies’ call for action comes just a month after the EU’s €2 billion (£1.73 billion) Innovative Medicines Initiative (IMI) announced the first two antimicrobial resistance projects in its ‘new drugs for bad bugs’ programme. Michael Goldman, executive director of IMI, tells Chemistry World that he was pleased that Davies is raising awareness among policymakers and the public of the threat posed by antibiotic resistance.

‘Chief medical officers are well placed to do this,’ he says, adding: ‘In the EU alone, antimicrobial resistance is responsible for some 25,000 deaths every year, and the annual treatment and social costs have been estimated at some €1.5 billion. If no steps are taken to address these issues, we risk leaving society in a situation where doctors will have few, if any, options to treat bacterial infections.’

Read more: here 

Stop putting them in the food! Duh!
-Moose

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GM Antibiotic Resistance in China’s Rivers

Via: Institute of Science in Society

 

 

Antibiotic resistance marker gene used in genetically modified crops found in bacteria isolated from all China’s rivers

Dr Eva Sirinathsinghji

Genetically engineered antibiotic resistance

A new study conducted in China finds 6 out of 6 major rivers tested positive for ampicillin antibiotic resistant bacteria [1]. Sequencing of the gene responsible, the blá gene, shows it is a synthetic version derived from a lab and different from the wild type. This suggests to the researchers that synthetic plasmid vectors from genetic engineering applications may be the source of the ampicillin resistance, which is affecting the human population. The blá gene confers resistance to a wide range of therapeutic antibiotics and the widespread environment pollution with blá resistant bacteria is a major public health concern.

The development of antibiotic resistant pathogens, commonly dubbed “superbugs”, are increasingly common due to the overuse of antibiotics in medical and veterinary practices, and the ever-increasing application of genetic engineering to industrial processes including agriculture, biofuel fermentation and environmental remediation on top of laboratory research. Previously, genetic engineering experiments were confined to the laboratory, but with industrial and agricultural applications becoming more common over the last decade, the chances of uncontrolled discharge as well as deliberate release into the environment has widened. One prime example is the planting of genetically modified (GM) crops, many of which carry antibiotic resistant genes.

Read more: here

GM Antibiotic Resistance in China’s Rivers

Via: Institute of Science in Society

 

 

Antibiotic resistance marker gene used in genetically modified crops found in bacteria isolated from all China’s rivers

Dr Eva Sirinathsinghji

Genetically engineered antibiotic resistance

A new study conducted in China finds 6 out of 6 major rivers tested positive for ampicillin antibiotic resistant bacteria [1]. Sequencing of the gene responsible, the blá gene, shows it is a synthetic version derived from a lab and different from the wild type. This suggests to the researchers that synthetic plasmid vectors from genetic engineering applications may be the source of the ampicillin resistance, which is affecting the human population. The blá gene confers resistance to a wide range of therapeutic antibiotics and the widespread environment pollution with blá resistant bacteria is a major public health concern.

The development of antibiotic resistant pathogens, commonly dubbed “superbugs”, are increasingly common due to the overuse of antibiotics in medical and veterinary practices, and the ever-increasing application of genetic engineering to industrial processes including agriculture, biofuel fermentation and environmental remediation on top of laboratory research. Previously, genetic engineering experiments were confined to the laboratory, but with industrial and agricultural applications becoming more common over the last decade, the chances of uncontrolled discharge as well as deliberate release into the environment has widened. One prime example is the planting of genetically modified (GM) crops, many of which carry antibiotic resistant genes.

Read more: here